Moderate fractionation RT-HYPO using IMRT combined with chemotherapy is feasible, with acceptable toxicity and favorable results in CCP-LA. The 2-year overall survival did not differ statistically between groups (RT-HIPO 66% vs RT-CONV-58%, p=0.08).
Compared RT-HIPO with RT -CONV, the samples were well matched for age, type of surgery, chemotherapy and site of treatment. The 2-year cancer-specific survival was 88%.85%.76%, and 81% for +RTHIPO surgery, +RTHIPO/QT surgery, RT-HIPO, and RT-HIPO/QT (p=0.221), respectively. In the last month or so of pregnancy, the baby kicks most during light. The 2-year OS per treatment group was 75%.64%, 56% and 65% (p=0.07) for surgery +RTHIPO, surgery +RTHIPO/QT, RT-HIPO and RT-HIPO/QT, respectively. Sometimes the fetus moves less during its sleep cycles. Resultadosĭuring the period 101 patients treated with the RT-HIPO scheme were included in the study, which were compared to the control group of 101 patients with conventional radiotherapy (RTCONV) for a total of 202 patients.The median follow-up was 28 months (9-38 months), the overall survival (OS) and the control location (CL) at 2 years was 51% and 67%. A matched sample of patients treated by conventional RT (RT-CONV) for sex, age, site of injury, clinical staging and type of treatment was used for survival comparison. Overall survival analysis and local control were performed using the Kaplan-Meier method. Operated patients underwent 56 Gy/25 fractions and 50 Gy/25 fractions in high-risk and low-risk CTV. Patients undergoing definitive RT with or without QT were treated with 64 Gy/25 fractions and 50 Gy/25 fractions in high- and low-risk CTV.
Inclusion criteria were diagnosis of CCP, age > 18 years, T3/T4 or N+ tumors, no distant metastases and no previous course of radiotherapy. Prospective cohort study, with paired analysis with historical cohort. Secondarily, overall survival was compared with a paired historical cohort treated with conventional dose RT. The primary objective was to evaluate the initial results of a prospective cohort of patients with CCP-LA treated with definitive radiotherapy or adjuvant radiotherapy with RT-HYPO with or without platinum-based chemotherapy. More recently, the results of some studies using the hypofractionated regimen demonstrate acceptable toxicity with similar oncologic results in the treatment of locally advanced CCP (CCP-LA). In recent years, RT-HIPO has been used in several tumors. The Journal expresses the voice of the Spanish Respiratory Society of Pulmonology and Thoracic Surgery (SEPAR) as well as that of other scientific societies such as the Latin American Thoracic Society (ALAT) and the Iberian American Association of Thoracic Surgery (AICT).Īuthors are also welcome to submit their articles to the Journal's open access companion title, Open Respiratory Archives.Moderate hypofractionated radiotherapy (RT-HIPO) in locally advanced head and neck cancer: a prospective cohort study with paired historical control using conventional radiotherapy (RT-CONV) Introdução Furthermore, the Journal is also present in Twitter and Facebook. Manuscripts will be submitted electronically using the following web site:, link which is also accessible through the main web page of Archivos de Bronconeumologia.Īccess to any published article, is possible through the Journal's web page as well as from PubMed, Science Direct, and other international databases.
The Journal is published monthly in English. It is a monthly Journal that publishes a total of 12 issues and a few supplements, which contain articles belonging to the different sections.Īll the manuscripts received in the Journal are evaluated by the Editors and sent to expert peer-review while handled by the Editor and/or an Associate Editor from the team. Other types of articles such as reviews, editorials, a few special articles of interest to the society and the editorial board, scientific letters, letters to the Editor, and clinical images are also published in the Journal. Archivos de Bronconeumologia is a scientific journal that preferentially publishes prospective original research articles whose content is based upon results dealing with several aspects of respiratory diseases such as epidemiology, pathophysiology, clinics, surgery, and basic investigation.
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